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本文研究了11例由慢性失血引起的缺铁性贫血患者,临床上具有不同程度的贫血症状,但所有病例均无合併症。在铁剂治疗之前,均进行常规的血液学检查及血清铁和铁结合力测定(后者显示血清铁降低和铁结合力增高),符合低血色素性贫血的诊断。还测定了珠蛋白链的比率。此外,用9名正常人作了对照。结果发现11例缺铁性贫血患者的外周红细胞α与β珠蛋白链比率为0.67～0.87,平均0.74±0.07;而9名正常人则为0.90～1.12,平均0.97±0.07,两者之间有显著差异(P<0.0005)。由此可见,缺铁性贫血患者的珠蛋白链比率明显低于正常人。经纯化溶血物和提纯珠蛋白后,比率虽增高至0.88±0.04,但仍明显低于正常。这些结果提示,在缺铁时α链的合
In this paper, 11 cases of iron deficiency anemia caused by chronic blood loss were studied, with varying degrees of clinical anemia, but no complications were found in all cases. Prior to iron treatment, routine hematology and serum iron and iron binding assays (the latter showing decreased serum iron and increased iron binding) were performed in line with the diagnosis of hypochromic anemia. The ratio of globin chains was also determined. In addition, nine normal controls were used. The results showed that 11 cases of iron deficiency anemia peripheral erythrocyte α and β globin chain ratio was 0.67 ~ 0.87, an average of 0.74 ± 0.07; and 9 normal people was 0.90 ~ 1.12, an average of 0.97 ± 0.07, between the two Significant difference (P <0.0005). Thus, the ratio of globin chains in patients with iron deficiency anemia was significantly lower than that in normal people. After purification of hemolysin and purified globin, although the ratio increased to 0.88 ± 0.04, but still significantly lower than normal. These results suggest that alpha-strand coalescence in iron deficiency