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目的比较莫西沙星两种不同给药方案治疗老年社区获得性肺炎的临床作用。方法选择我院2010年10月~2011年12月收治的108例老年社区获得性肺炎患者并随机分为两组,对照组54例常规应用莫西沙星静脉滴注治疗,观察组54例采用莫西沙星序贯治疗,比较两组的临床疗效及药物经济学情况。结果观察组总有效率98.1%,对照组为94.4%,组间差异无统计学意义(P>0.05);观察组不良反应发生率为3.7%,对照组为7.4%,组间差异无统计学意义(P>0.05);观察组的平均治疗费是1834.9元,明显低于对照组的3787.1元。结论莫西沙星两种不同给药方案治疗老年社区获得性肺炎均可获得满意的临床疗效,且安全性好,但序贯疗法成本-效果比低,是首选的治疗方案。
Objective To compare the clinical effects of two different dosage regimens of moxifloxacin in the treatment of elderly community-acquired pneumonia. Methods A total of 108 elderly patients with community-acquired pneumonia admitted to our hospital from October 2010 to December 2011 were randomly divided into two groups. In the control group, 54 cases were treated with moxifloxacin intravenously. In the observation group, 54 cases were treated with Mo Xisha sequential treatment, the two groups were compared the clinical efficacy and drug economics. Results The total effective rate was 98.1% in the observation group and 94.4% in the control group, with no significant difference between the two groups (P> 0.05). The incidence of adverse reactions in the observation group was 3.7% and in the control group was 7.4% (P> 0.05). The average treatment cost of the observation group was 1834.9 yuan, which was obviously lower than that of the control group (3787.1 yuan). Conclusion Both moxifloxacin dosing regimens for elderly community-acquired pneumonia can achieve satisfactory clinical efficacy with good safety, but the cost-effectiveness ratio of sequential therapy is the preferred treatment option.