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Objective. Comparison of 123I-metaiodobenzylguanidine (MIBG) scintigraphy and magnetic resonance imaging (MRI) in the detection of single neuroblastoma lesio ns and assessment of the benefit of combined analysis. Materials and methods. Fi fty 123I-MIBG and 50 MRI examinations in 28 pediatric patients (mean interval 6 .4 days) were evaluated retrospectively by two independent observers each for ne uroblastoma lesions (n=193). Subsequently, the same observers performed a combin ed analysis. MIBG and MRI findings as well as the findings of the combined analy sis were verified by clinical and histological data. Results. In the detection o f single neuroblastoma lesions, MIBG/MRI showed a sensitivity of 69%/86%and a specificity of 85%/77%. In combined imaging, a sensitivity of 99%and a specif icity of 95%were found. Conclusion. MRI showed a higher sensitivity and MIBG sc intigraphy a higher specificity in the assessment of pediatric neuroblastoma les ions. There was a clear increase in both parameters on combined imaging.
Objective. Comparison of 123I-metaiodobenzylguanidine (MIBG) scintigraphy and magnetic resonance imaging (MRI) in the detection of single neuroblastoma lesion ns and assessment of the benefit of combined analysis. Materials and methods. Fi fty 123I-MIBG and 50 MRI examinations in 28 Pediatric patients (mean interval 6 .4 days) were evaluated retrospectively by two independent observers each for neuroblastoma lesions (n = 193). Both the same observers performed a combin ed analysis. MIBG and MRI findings as well as the findings of the In combined imaging, a sensitivity of 69% / 86% and a specificity of 85% / 77%. In combined imaging, a sensitivity of 99% and a specif icity of 95% were found. Conclusion. MRI showed a higher sensitivity and MIBG sc intigraphy a higher specificity in the assessment of pediatric neuroblastoma les ions. There was a clear increase in both parameters on combined imaging.