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目的:观察清伙灵的抗炎效果,以探讨其对治疗小儿上火证的作用机制。方法:采用角叉菜胶诱导大鼠足肿胀急性炎症模型及棉球诱导的大鼠肉芽组织增生慢性炎症模型进行实验,同时检测急性炎症大鼠模型红细胞沉降率(ESR)、C-反应蛋白(CRP),观察清伙灵和配方的抗炎作用。结果:清伙灵配方Ⅰ高剂量组、配方Ⅱ高、低剂量组和清伙灵组可明显抑制角叉菜胶引发的大鼠足肿胀和棉球引起的大鼠肉芽肿,降低ESR和CRP,与模型对照组比较差异均有统计学意义(P<0.01或P<0.05)。结论:清伙灵和配方均有明显的抗炎作用,体现了清热泻火的功效。
Objective: To observe the anti-inflammatory effect of Qing-Zhuo Ling to explore its mechanism of treatment of children’s fire-card. Methods: Carrageenin-induced rat acute foot swelling model and chronic granulomatous rat model of granulation tissue hyperplasia induced by cotton ball were used in the experiment. The erythrocyte sedimentation rate (ESR), C-reactive protein CRP), observe the anti-inflammatory effect of Qing Guoling and formula. Results: High-dose Qingliao recipe Ⅰ, high-dose and low-dose formula Ⅱ group and Qingliao Ling group can significantly inhibit carrageenan-induced rat paw swelling and cotton ball-induced granuloma in rats, reducing ESR and CRP , There was significant difference compared with the model control group (P <0.01 or P <0.05). Conclusion: Qing Gu Ling and formula have obvious anti-inflammatory effect, reflecting the efficacy of heat purging fire.