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作者用单向免疫扩散法对61例典型流行性出血热(EHF)患者血浆纤维结合蛋白(Fn)水平进行动态观察,并以60例健康献血员为对照。结果显示,正常对照值为325.5±94.5mg/L,EHF患者发热期Fn水平下降至226.7±78.5mg/L,至恢复期已明显回升至311.4±82.3mg/L.血浆Fn下降水平与病情的严重程度和血小板计数下降呈正相关(r=0.91,P<0.01)亦与循环免疫复合物的升高呈负相关(r=-0.920,P<0.05)提示血浆Fn水平可作为判断预后的指标;适当补充Fn制剂、对危重病例改善肾功及出血症状、缩短病程、降低病死率或许会有所裨益。
The authors used one-way immunodiffusion method to observe the level of plasma fibronectin (Fn) in 61 cases of typical epidemic hemorrhagic fever (EHF), and compared 60 healthy blood donors. The results showed that the normal control value was 325.5 ± 94.5mg / L, EHF patients during the fever Fn level decreased to 226.7 ± 78.5mg / L, to the recovery period has significantly recovered to 311.4 ± 82.3mg / L. Plasma Fn decreased with the disease There was a positive correlation between the severity and the decrease of platelet count (r = 0.91, P <0.01) and negative correlation with the increase of circulating immune complex (r = -0.920, P <0.05) Proper supplementation of Fn preparations, for critical cases to improve kidney function and bleeding symptoms, shorten the course of the disease, reduce mortality may be of benefit.