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目的:研究粘附分子β1整合素与MMP-9在子宫内膜癌中的表达与病理学分级等因素间的关系。方法:应用免疫组织化学S-P法检测37例子宫内膜癌及10例正常子宫内膜组织中β1整合素和MMP-9的表达情况,分析二者与子宫内膜癌之间的关系。结果:β1整合素的阳性表达率在子宫内膜癌中明显高于正常子宫内膜(P<0.05),与子宫内膜癌的病理学分级无相关关系(P>0.05)。MMP-9的阳性表达率在子宫内膜癌中明显高于正常子宫内膜(P<0.05),与病理学分级相关(P<0.05),其阳性表达率随着病理学分级的递增而增高。子宫内膜癌中β1整合素与MMP-9的阳性表达率呈正相关关系(P<0.05)。结论:β1整合素和MMP-9与子宫内膜癌的发生发展有关,联合检测β1整合素和MMP-9在子宫内膜癌中的表达,对于辅助判断子宫内膜癌的恶性程度、转移潜能及预后有重要的参考价值。
Objective: To study the relationship between the expression of adhesion molecule β1 integrin and MMP-9 in endometrial carcinoma and pathological grade. Methods: The expressions of β1 integrin and MMP-9 in 37 cases of endometrial carcinoma and 10 cases of normal endometrium were detected by immunohistochemical S-P method. The relationship between them and endometrial carcinoma was analyzed. Results: The positive rate of β1 integrin was significantly higher in endometrial carcinoma than in normal endometrium (P <0.05), but not with the pathological grade of endometrial carcinoma (P> 0.05). The positive rate of MMP-9 in endometrial carcinoma was significantly higher than that in normal endometrium (P <0.05), which was correlated with pathological grade (P <0.05). The positive expression rate of MMP-9 increased with the increase of pathological grade . The positive rate of β1 integrin and MMP-9 in endometrial carcinoma was positively correlated (P <0.05). Conclusion: The expressions of β1 integrin and MMP-9 are correlated with the occurrence and development of endometrial carcinoma. The combined detection of the expression of β1 integrin and MMP-9 in endometrial carcinoma may be helpful in judging the malignancy and metastasis potential of endometrial carcinoma And the prognosis has important reference value.