论文部分内容阅读
目的观察中西医结合治疗小儿病毒性心肌炎的临床疗效及安全性,为小儿病毒性心肌炎的治疗提供临床依据。方法选取本院2013年6月至2014年10月收治的病毒性心肌炎患儿96例,按照随机数字表法分为2组,每组48例。对照组采用西医常规治疗,治疗组在对照组治疗方法的基础上联合中药进行治疗,观察2组的临床疗效,治疗前后心肌酶的变化情况及射血分数(LVEF)、每搏输出量(SV)、心输出量(CO)等心功能指标。结果治疗组总有效率为93.75%,显著高于对照组的54.17%,2组比较差异有统计意义(P<0.05);治疗后2组LVEF,SV,CO均显著升高,与同组治疗前比较,差异均有统计意义(P<0.05),且治疗组各项指标显著高于对照组,差异有统计意义(P<0.05);治疗后2组肌酸激酶(CKMB)、α-羟丁酸脱氢酶(HBDH)含量均显著降低,与同组治疗前比较,差异均有统计意义(P<0.05),且治疗组CKMB,HBDH含量显著低于对照组,差异有统计意义(P<0.05)。结论中西医结合治疗小儿病毒性心肌炎疗效显著,且安全性高,值得临床推广应用。
Objective To observe the clinical efficacy and safety of integrated traditional Chinese and western medicine in the treatment of viral myocarditis in children and provide the clinical evidence for the treatment of viral myocarditis in children. Methods Ninety-six children with viral myocarditis admitted from June 2013 to October 2014 in our hospital were divided into two groups (n = 48) according to random number table. The control group was treated with conventional western medicine. The treatment group was treated with traditional Chinese medicine on the basis of the control group. The clinical curative effect, the change of myocardial enzyme and the ejection fraction (LVEF), stroke volume ), Cardiac output (CO) and other cardiac function indicators. Results The total effective rate in the treatment group was 93.75%, significantly higher than that in the control group (54.17%), the difference between the two groups was statistically significant (P <0.05). After treatment, the LVEF, SV and CO in the two groups were significantly increased, (P <0.05), and the indexes in the treatment group were significantly higher than those in the control group (P <0.05). After treatment, the levels of CKMB, Butyrate dehydrogenase (HBDH) were significantly decreased compared with the same group before treatment, the difference was statistically significant (P <0.05), and the treatment group CKMB, HBDH content was significantly lower than the control group, the difference was statistically significant (P <0.05). Conclusion Integrative treatment of children with viral myocarditis significant effect, and high safety, it is worth promoting the clinical application.