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目的 比较PCNA和RAR -α染色对HCC增殖的评估和相互关系。方法 对 4 4例肝细胞癌病例的石蜡切片 ,用免疫组化染色法 ,分别行增殖核抗原和维甲酸α核受体染色 ,比较两者对HCC增殖的评估和相互关系。结果 PCNA在HCCs中的阳性率为 34.8% ,RAR -α在HCCs中的阳性率为 36 .4 % ;HCC分化越差 ,PCNA和RAR -α阳性率越高 ,同时 ,我们证实PCNA和RAR -α在原发性肝细胞癌中的阳性率有十分密切的正相关关系。结论 RAR -α与PCNA可用来评估HCC的增殖
Objective To evaluate the relationship between PCNA and RAR-α staining on the proliferation of HCC. Methods Paraffin sections from 44 cases of hepatocellular carcinoma were stained with immunohistochemical staining for proliferating nuclear antigen and retinoic acid α nuclear receptor respectively. The evaluation and correlation of the two on the proliferation of HCC were compared. Results The positive rate of PCNA in HCCs was 34.8% and the positive rate of RAR-α in HCCs was 36.4%. The worsened HCC differentiation was, the higher the positive rates of PCNA and RAR-α were. Meanwhile, we confirmed that PCNA and RAR - α positive rate in primary hepatocellular carcinoma have a very close positive correlation. Conclusion RAR-α and PCNA can be used to assess the proliferation of HCC