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目的 :探讨 2型糖尿病患者骨代谢生化指标的临床意义。方法 :对 4 0例 2型糖尿病患者及 31例正常人进行血骨钙素 (BGP)、钙 (Ca)、碱性磷酸酶 (ALP) ;尿脱氧吡啶啉 (DPD)、Ca、肌酐 (Cr)测定。结果 :糖尿病组血清BGP较正常对照组明显降低 (P <0 0 5 ) ;尿DPD/Cr比值 ,Ca/Cr比值显著高于正常对照组 (P <0 .0 5 ,P <0 .0 5 ) ;血清Ca、ALP两组无统计学差异。结论 :2型糖尿病患者骨代谢异常引发骨量减少、骨质疏松与骨形成减少和骨吸收增加有关 ;血BGP、尿DPD/Cr、Ca/Cr可作为早期诊断糖尿病骨量减少、骨质疏松敏感的骨代谢生化指标。
Objective: To investigate the clinical significance of biochemical markers of bone metabolism in type 2 diabetic patients. Methods: Serum BGP, Ca, ALP, DPD, Cr, Cr (Cr) were measured in 40 patients with type 2 diabetes and 31 normal controls. ). Results: Serum BGP in diabetic group was significantly lower than that in normal control group (P <0.05); DPD / Cr ratio and Ca / Cr ratio in urine were significantly higher than those in normal control group (P <0.05, P <0.05 ); Serum Ca, ALP no significant difference between the two groups. CONCLUSIONS: Patients with type 2 diabetes mellitus have abnormal bone metabolism, osteopenia and osteoporosis with decreased bone formation and increased bone resorption. Serum BGP, urinary DPD / Cr and Ca / Cr may serve as early diagnoses of osteopenia, osteoporosis Sensitive biochemical markers of bone metabolism.