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高钙血症对肾脏组织和功能有一定的损伤作用,在仅有高钙尿而无高钙血的患者一般很少有肾脏组织和功能的损伤。实验性高钙血症可在数小时内引起肾小球滤过率减低和肾浓缩功能障碍。高钙血24～48小时后即可有肾脏超微结构改变。长期高钙血症可引起钙在肾脏内广泛沉积(肾钙化症)。即使血钙恢复正常后很久,肾脏的病变和功能障碍仍可继续存在。所以有些患者在诊断为肾钙化症前后,可能并未发现高钙血。
Hypercalcaemia has some damage to the kidney tissue and function. In patients with hypercalciuria and without hypercalcemia, there are few renal tissue and functional injuries. Experimental hypercalcaemia can cause glomerular filtration rate reduction and renal condensation dysfunction within hours. Hypercalcemia 24 to 48 hours after the kidneys can have ultrastructural changes. Long-term hypercalcaemia causes extensive deposition of calcium within the kidney (nephrogenic calcification). Even after the serum calcium is restored to normal for a long time, the lesions and dysfunction of the kidneys can still exist. So some patients before and after the diagnosis of renal calcification, may not find hypercalcemia.