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目的定位免疫功能相关的中枢脑区。方法以大鼠脑内细胞因子 IL- 1β、 IL- 6、 IL- 2和 TGF-β 1的表达为观察指标 ,应用免疫组化 ABC法和免疫荧光法 ,比较不同免疫状态大鼠与正常对照大鼠脑内 IL- 1β、 IL- 6、 IL- 2和 TGF-β 1阳性细胞的分布，以及细胞因子的表达与免疫状态的关系；分析 IL- 1β、 IL- 6和 TGF-β 1阳性细胞的细胞性质。结果（ 1）在免疫组和对照组大鼠多个脑区中观察到 IL- 1β、 IL- 6和 TGF-β 1阳性细胞的分布，但仅有下丘脑外侧区 (LH)和前杏仁核（ AA）内 IL- 1β、 IL- 6和 TGF-β 1的表达与大鼠是否被抗原免疫有关。（ 2）细胞双标记证明表达细胞因子的细胞为神经元。结论下丘脑外侧区和前杏仁核为参与神经免疫调节功能的特定脑区之一，该脑区的神经免疫调节功能是通过神经源性细胞因子介导实现的。
Objective To locate the central nervous system related to immune function. Methods The expressions of IL-1β, IL-6, IL-2 and TGF-β1 in rat brain were observed. Immunohistochemical ABC method and immunofluorescence method were used to compare the expression of IL-1β, IL- The distribution of IL-1β, IL-6, IL-2 and TGF-β1 positive cells in rat brain and the relationship between the expression of cytokines and immune status were analyzed. The positive expression of IL-1β, IL-6 and TGF- The cellular nature of the cell. Results (1) The distribution of IL-1β, IL-6 and TGF-β1 positive cells was observed in multiple brain regions in the immunized group and the control group, but only in the lateral hypothalamic area (LH) and the amygdala (AA) IL-1β, IL-6 and TGF-β1 expression and whether the immune immune antigen. (2) Cell double labeling proves that cells expressing cytokines are neurons. Conclusions The lateral hypothalamic area and the amygdala are one of the specific brain regions involved in neuroimmunoregulatory function. The neuroimmunoregulatory function of the brain region is mediated by neurogenic cytokines.