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尽管对乳癌的深入认识及检查方法的增多，但在美国仍有多达20％的局部晚期乳癌（LABC）。术前或加术后放疗对LABC局部控制虽可达70%～86％，但主要失败于全身转移，为此近20年针对其原因的辅助化疗用于LABC已不足为奇。Delena首先提出手术和放疗消除局部肿瘤；化疗消灭微转移灶，“可能治愈”LABC的观念，并作为LASC的标准治疗方素。本文介绍了包括诱导化疗对LABC综合治疗的初步经验。
Despite deeper understanding of breast cancer and increased inspection methods, up to 20% of locally advanced breast cancer (LABC) is still present in the United States. Although local control of LABC can reach 70% to 86% before or after radiotherapy, it mainly fails to metastasize to the body. For this reason, it is not surprising that adjuvant chemotherapy for LAC was used in the past 20 years. Delena first proposed surgery and radiotherapy to eliminate local tumors; chemotherapy eradicated micrometastases, “may cure” the concept of LABC, and as a standard treatment of LASC. This article describes preliminary experiences including induction chemotherapy for LABC.