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目的探讨血清胃泌素（ＧＡＳ）、癌胚抗原（ＣＥＡ）对大肠癌的诊断价值。方法采用放射免疫法（ＲＩＡ）测定大肠癌（６０例）、胃癌（４０例）、肝癌（３０例）、消化系统良性疾病（４０例）及正常人（３０例）的ＧＡＳ与ＣＥＡ水平。结果大肠癌组、胃癌组ＧＡＳ均显著高于正常组（Ｐ＜０．０１），两癌组间差异不显著（Ｐ＞０．０５），肝癌组、消化系良性疾病组与正常组间差异无显著性（Ｐ＞０．０５）。大肠癌组ＧＡＳ术后显著下降（Ｐ＜０．００１）。不同病变部位ＧＡＳ、ＣＥＡ差异无显著性（Ｐ＞０．０５）。分化良好腺癌的ＧＡＳ、ＣＥＡ均稍高于中、低分化癌。结论血清ＧＡＳ、ＣＥＡ检测可做为普查筛选大肠癌的一项客观指标，但ＣＥＡ敏感性很低，远逊于ＧＡＳ，胃癌组与大肠癌组间有交叉重叠，须注意鉴别。ＧＡＳ对判断手术疗效及细胞分化程度有参考价值。
Objective To investigate the diagnostic value of serum gastrin (GAS) and carcinoembryonic antigen (CEA) in colorectal cancer. Methods The levels of GAS and CEA in colorectal cancer (60 cases), gastric cancer (40 cases), liver cancer (30 cases), benign diseases of digestive system (40 cases) and normal persons (30 cases) were determined by radioimmunoassay (RIA). Results The GAS in colorectal cancer and gastric cancer were significantly higher than those in the normal group (P<0.01). There was no significant difference between the two cancer groups (P>0.05). The differences between the liver cancer group and the benign diseases of the digestive system were compared with the normal group. No significant (P>0.05). The colorectal cancer group significantly decreased after GAS (P<0.001). There was no significant difference in GAS and CEA between different lesions (P>0.05). GAS and CEA with well-differentiated adenocarcinoma were slightly higher than those with moderately differentiated carcinoma. Conclusion The detection of serum GAS and CEA can be used as an objective index for the screening of colorectal cancer. However, the sensitivity of CEA is much lower than that of GAS. There is overlap between gastric cancer group and colorectal cancer group. GAS has a reference value for judging the efficacy of surgery and cell differentiation.