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应用生物素化花生凝集素(PNA)对胎肺及45例肺癌进行组织化学研究.结果显示:胎肺内支气管上皮顶部胞膜及胞质呈PNA阳性.肺鳞癌及肺腺癌PNA受体增多,且分布失去极性.本文提示PNA受体改变可作为内胚层肿瘤的标志之一,尤其对腺癌有相对特异性.PNA受体在胚胎及肺癌均表达可能提示PNA是一种癌胚抗原.
Biotinylated peanut agglutinin (PNA) was used to study fetal lung and 45 cases of lung cancer. The results showed that the apical membrane and cytoplasm of fetal lung were PNA positive. Lung squamous cell carcinoma and lung adenocarcinoma PNA receptor Increased, and the distribution of loss of polarity. This paper suggests that PNA receptor changes can be used as one of the hallmarks of endodermal tumors, especially for adenocarcinoma with relative specificity. PNA receptor expression in embryos and lung cancer may suggest that PNA is a cancer embryo antigen.