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3—二甲胺基丙腈与氯在缓和的条件下反应即生成四氯嘧啶,本文通过波谱分析确定了氯化过程中间产物的水解产物,并由它们判断出中间产物的结构,进而提出了由3—二甲胺基丙腈合成四氯嘧啶的反应历程。即:3—二甲胺基丙腈分子中的α氢原子首先被氯原子取代。接着β氢原子被取代,然后分子中甲基氢原子被氯取代,并发生环合及芳构化反应生成1—甲基—2,4,5,6—四氯嘧啶氯化物,后者在60—120℃发生脱烷基反应而转变为四氯嘧啶。
3 - dimethylaminopropionitrile and chlorine under mild conditions to generate tetrachloropyrimidine, the paper determined by spectroscopic analysis of the hydrolysis products of the intermediate products of chlorination, and from them to determine the structure of the intermediate product, and then put forward Synthesis of tetrachloropyrimidine from 3-dimethylaminopropionitrile. That is, the α-hydrogen atom in the 3-dimethylaminopropionitrile molecule is first replaced by a chlorine atom. Then β-hydrogen atoms are replaced, and then the molecule of methyl hydrogen atoms are replaced by chlorine, and the occurrence of cyclization and aromatization reaction 1-methyl-2,4,5,6-tetrachloropyrimidine chloride, the latter in the 60-120 ° C dealkylation reaction into tetrachloropyrimidine.