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目的:探讨几丁糖预防人工流产术后宫腔粘连的临床应用价值。方法:将400例因早孕要求进行人工流产手术的重复流产患者按随机数字表法分组,即几丁糖子宫腔内局部应用组(试验组)及无任何干预措施组(对照组),对两组病例手术中情况、术后月经量变化情况、宫腔改变情况进行比较。结果:两组病例的一般情况、手术中情况无差异;手术时间无差异(t=0.953,P=0.341);术后绒毛大小无差异(t=-0.256,P=0.799);术后月经量减少30%～50%者试验组为6例,对照组为19例;术后月经量减少≥50%者试验组2例,对照组6例,两组差异有统计学意义(χ2=9.55,P=0.005);术后发生宫腔粘连试验组2例,对照组6例,两组差异有统计学意义(χ2=7.35,P=0.007)。结论:宫腔内应用几丁糖可以减少人工流产术后宫腔粘连的发病几率,是一种操作简便、疗效满意的预防方案。
Objective: To investigate the clinical value of chitosan in preventing intrauterine adhesions after induced abortion. Methods: Four hundred patients with repeated abortion requiring abortion due to early pregnancy were divided into two groups according to random number table: local application group (experimental group) and no intervention group (control group) Group cases of surgery, changes in postoperative menstrual flow, uterine cavity changes were compared. Results: There was no difference in operation between the two groups. There was no difference in operation time (t = 0.953, P = 0.341). There was no difference in the size of villus after operation (t = -0.256, P = 0.799) There were 6 cases in the test group and 19 cases in the control group after reduction of 30% ~ 50%, 2 cases in the test group and 6 cases in the control group after the menstruation was reduced by 50% (χ2 = 9.55, P = 0.005). There were 2 cases of intrauterine adhesions test group and 6 cases of control group postoperatively. The difference between the two groups was statistically significant (χ2 = 7.35, P = 0.007). Conclusion: The application of chitosan in uterine cavity can reduce the incidence of uterine adhesions after induced abortion, which is a simple and effective preventive plan.