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钙粘蛋白复合体是近10a来发现的细胞信号转导系统,他与细胞间紧密连接的建立、细胞极性的维持、伤口的愈合以及肿瘤的发生和发展等多种生理和病理过程有着密切的关系。此复合体中的α-连环素对其有独立的调控作用,其表达情况是反映此复合体功能的敏感指标。检测肿瘤组织中α-连环素的表达有助于对肿瘤的生物学表型作出判断,对患者预后的估计也有帮助。本文综述了近年来关于α-连环素的生物学性质、功能调控、α-连环素在胃肠道肿瘤中的表达特点以及α-连环素的检测方法。
Cadherin complex is a cell signal transduction system discovered in recent 10 years. He has close relationship with the establishment of tight intercellular connection, the maintenance of cell polarity, the healing of wounds and the occurrence and development of tumors and other physiological and pathological processes Relationship. The α-catenin in this complex has its own regulatory role, and its expression is a sensitive indicator of the complex’s function. Detecting the expression of α-catenin in tumor tissue can help to judge the biological phenotype of the tumor and also help to estimate the prognosis of patients. This review summarizes the recent years on the biological properties of α-catenin, functional regulation, α-catenin expression in gastrointestinal tumors and α-catenin detection.