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目的:探讨阿司匹林与厄贝沙坦联用治疗老年患者急性脑梗死的疗效及其对血液流变学、超敏C反应蛋白(Hs-CRP)和神经功能的影响。方法:选取2013年9月—2016年12月间收治的急性脑梗死老年患者81例,将其分为对照组41例和观察组41例;对照组患者给予阿司匹林治疗,观察组患者在对照组基础上加用厄贝沙坦治疗,比较两组患者治疗前后APTT,PT,D-D等凝血功能以及Hs-CRP及神经功能(NIHSS评分)改善情况和总有效率。结果:治疗后患者Hs-CRP、D-D、NIHSS评分值均下降,APTT、PT则延长,与治疗前比较其差异有统计学意义(P<0.05);治疗后观察组患者Hs-CRP、D-D、NIHSS评分值低于对照组,而APTT、PT水平则大于对照组(P<0.05);观察组患者治疗后的总有效率为95.00%高于对照组为73.17%(P<0.05。结论:采用阿司匹林与厄贝沙坦联用治疗急性脑梗死老年患者,疗效较显著,可有效改善脑梗后再灌注,促进神经功能的恢复。
Objective: To investigate the efficacy of aspirin and irbesartan in the treatment of acute cerebral infarction in elderly patients and its effect on hemorrheology, Hs-CRP and neurological function. Methods: Seventy-one elderly patients with acute cerebral infarction who were admitted to our hospital from September 2013 to December 2016 were divided into control group (41 cases) and observation group (41 cases). Patients in the control group were given aspirin, while patients in the observation group Based on the use of irbesartan treatment, the two groups of patients before and after treatment APTT, PT, DD and other coagulation function and Hs-CRP and neurological function (NIHSS score) to improve the situation and the total efficiency. Results: After treatment, the scores of Hs-CRP, DD and NIHSS decreased, but APTT and PT were prolonged. There was significant difference between before and after treatment (P <0.05) The NIHSS score was lower than that of the control group, but the level of APTT and PT was higher than that of the control group (P <0.05). The total effective rate of the observation group was 95.00% after treatment, which was 73.17% (P <0.05) .Conclusion: Aspirin and irbesartan combined treatment of elderly patients with acute cerebral infarction, the effect is more significant, can effectively improve cerebral infarction reperfusion, and promote the recovery of nerve function.