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目的:探讨氧氟沙星联合阿莫西林克拉维酸钾治疗耐多药肺结核的临床疗效。方法:抽取2011年5月-2013年6月昆明市第三人民医院收治的耐多药肺结核患者100例,按临床治疗意愿分成两组(观察组、对照组),分别给予不同药物治疗,比较两组患者临床疗效。结果:临床结果显示,观察组痰菌转阴率、病灶吸收率、肺结核闭合率和对照组相比,差异有统计学意义(P<0.05);两组患者均出现肠胃反应、尿酸升高等不良反应,差异无统计学意义(P>0.05)。结论:氧氟沙星联合阿莫西林克拉维酸钾治疗耐多药肺结核患者,临床效果显著,不良反应少,吸收性强。
Objective: To investigate the clinical efficacy of ofloxacin combined with amoxicillin and clavulanate potassium in the treatment of multidrug-resistant pulmonary tuberculosis. Methods: A total of 100 MDR-TB patients admitted to the Third People’s Hospital of Kunming from May 2011 to June 2013 were selected and divided into two groups (observation group and control group) according to the intention of clinical treatment. The patients were given different drugs and compared with each other Clinical efficacy of two groups of patients. Results: The clinical results showed that there was a significant difference between the observation group and the control group (P <0.05). The incidences of gastrointestinal reactions and elevated uric acid in both groups were significantly higher than those in the control group Reaction, the difference was not statistically significant (P> 0.05). Conclusion: Ofloxacin combined with amoxicillin and clavulanate potassium in the treatment of MDR-TB patients has significant clinical effect, less adverse reactions and strong absorption.