论文部分内容阅读
微小病变型肾病综合征(MCNS)的发病机制到目前为止仍不清楚,有研究发现免疫学异常,尤其是T细胞异常参与了MCNS的发生,作者用灵敏的免疫萤光法测定MCNS患者血清中三种类风湿因子(RF)观察它们在病程中的变化以探讨类风湿因子在MCNS发病中的作用和临床意义。材料和方法:20例MCNS患者,男12例、女8例,肾活检确诊为MCNS,8例肾病综合征期,8例应用激素缓解期,4例未用激素完全缓解期,所有MCNS患者肾功能正常,10例类风湿性关节炎和30例正常人分别作为阳性对照和阴性对照,类风湿因子采用固相免疫萤光法测定,同时采用常规的血清学类风湿因子试验如乳胶固定试验(RA试验)和致敏红
The pathogenesis of minimal nephrotic syndrome (MCNS) remains unclear. Some studies have found that immunological abnormalities, especially T cell abnormalities, are involved in the development of MCNS. The authors used sensitive immunofluorescence to determine the serum levels of MCNS Three types of rheumatoid factor (RF) observed their changes in the course of the disease to explore the role of rheumatoid factor in the pathogenesis of MCNS and clinical significance. MATERIALS AND METHODS: Twenty patients with MCNS were enrolled in this study. There were 12 males and 8 females. The patients were diagnosed as MCNS by renal biopsy, 8 cases with nephrotic syndrome, 8 cases with hormone remission, 4 cases without hormone remission, Normal function, 10 cases of rheumatoid arthritis and 30 normal people were used as positive control and negative control respectively. Rheumatoid factor was determined by solid phase immunofluorescence method, and routine routine serum rheumatoid factor test such as latex fixation test RA test) and sensitized red