论文部分内容阅读
目的:探讨清心镇肝汤对心火上炎、肝风内动型围绝经期失眠患者的睡眠质量、血清5-HT、5-HIAA水平的影响.方法:将110例诊断为心火上炎、肝风内动型围绝经期失眠的患者随机分为治疗组、对照组,治疗结束后针对两组患者睡眠质量、血清5-HT及5-HIAA水平进行统计学分析.结果:两组患者的睡眠质量均改善,血清5-HT均增加,5-HIAA水平均降低(P＜0.01).其中治疗组改善患者睡眠质量和血清单胺类递质水平的效果更加显著(P＜0.05).结论:清心镇肝汤能较好改善心火上炎、肝风内动型围绝经期失眠患者的睡眠质量,其机制可能与增加血清中5-HT,降低5-HIAA水平有关.“,”Objective:To investigate the effect of the Qingxin Zhengan decoction (清心镇肝汤,QXZGD) on sleep quality and the serum level of 5-HT,5-HIAA of perimenopausal insomnia patients.Methods:The 110 patients diagnosed with exuberance of heart fire,liver wind agitation type perimenopausal insomnia were randomly divided into treatment group and control group,after treatment,the sleep quality,serum 5-HT and 5-HIAA levels of the two groups were statistically analyzed.Results:The sleep quality of the two groups improved,serum 5-HT increased,and 5-HIAA levels decreased (P＜0.01).In the treatment group,the effect of improving sleep quality and serum monoamine neurotransmitter level was more significant (P＜0.05).Conclusion:QXZGD can improve the exuberance of heart fire,liver wind agitation type perimenopausal patients with insomnia sleep quality and its mechanism may be related to increase in serum 5-HT,lower levels of 5-HIAA.