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目的:研究靖江地区各组宫颈病变中高危型人乳头瘤病毒(HPV)感染率及其基因型分布。方法:采用实时荧光PCR检测方法检测334例宫颈脱落细胞标本中高危型HPV及其基因型。结果:高危型HPV在宫颈炎组、湿疣组、低度鳞状上皮细胞内病变(LSIL)组、高度鳞状上皮细胞内病变(HSIL)组中的感染率分别为24.2%、58.2%、49.3%、69.5%;HPV 16、18、33、58型在宫颈病变中是最常见的HPV型别,其中,HPV16型在宫颈炎组、湿疣组、LSIL组、HSIL组中所占比例逐渐增高,分别为17.9%、18.9%、30.8%、41.9%。结论:高危型HPV感染率随着宫颈病变程度的加重而升高,HPV16型是高危型HPV感染中的主要亚型,HPV18、33、52、58也较常见,其余型别很少。
Objective: To investigate the prevalence and genotype distribution of high-risk human papillomavirus (HPV) in various cervical lesions in Jingjiang area. Methods: Real-time PCR was used to detect high-risk HPV genotypes in 334 cervical exfoliated cells. Results: The infection rates of high risk HPV in cervicitis group, genital warts group, LSIL group and HSIL group were 24.2%, 58.2%, 49.3 %, 69.5%. HPV type 16, 18, 33 and 58 were the most common HPV types in cervical lesions. HPV16 type gradually increased in cervicitis group, genital warts group, LSIL group and HSIL group, Respectively 17.9%, 18.9%, 30.8% and 41.9%. Conclusion: The prevalence of high-risk HPV infection increases with the severity of cervical lesions. HPV16 is the major subtype in high-risk HPV infection. HPV18, 33, 52 and 58 are also common, and the rest are rare.