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实验用离体兔主动脉条和回肠进行。实验证明阿托品可使去甲肾上腺素(NA)的量效曲线平行右移。在所用阿托品的浓度下,并不明显降低NA的最大收缩反应。常用的阿托品类药物多有类似的抗去甲肾上腺素作用,其强度顺序为:阿托品,山莨菪碱、东莨菪碱;而樟柳碱基本上无抗NA作用。剂量比率试验证明,阿托品是一个作用机制与酚妥拉明相似的NA拮抗剂。交叉保护试验证明,阿托品能对苯苄胺的阻断提供明显的保护作用。在离体兔回肠的实验中证明,阿托品对α受体的抑制性效应也有选择性对抗作用。根据上述结果可以认为,阿托品类生物碱的抗肾上腺素作用很可能是竞争性的对α受体的阻断。并认为此阻断作用可能与此类药物在感染性休克和某些疾病时的治疗作用有关。
Experiments with isolated rabbit aortic strips and ileum. Experiments have shown that atropine can shift the dose-response curve of norepinephrine (NA) to the right. At the concentrations of atropine used, the maximal contractile response to NA was not significantly reduced. Commonly used atropine drugs have a similar anti-norepinephrine effect, the intensity of the order: atropine, anisodamine, scopolamine; and anisodine basically no anti-NA effect. Dose-ratio tests have shown that atropine is a potent NA antagonist with phentolamine. Cross protection test proved that atropine can block benzene benzene amine provide significant protection. Experiments in isolated rabbit ileum demonstrated that atropine also exerts a selective antagonistic effect on the inhibitory effects of alpha receptors. Based on the above results, it can be concluded that the anti-epinephrine action of atropine alkaloids is likely to be a competitive blocker of alpha receptors. And that this blockade may be related to the therapeutic effect of such drugs in septic shock and certain diseases.