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质谱应用于天然产物分析是从本世纪60年代开始。然而,早期的质谱,诸如电子轰击质谱(EIMS)、化学电离质谱(CIMS)或场解吸质谱(FDMS)等技术只能用于中、小有机化合物分子的解析。这些技术对样品的要求高,样品的前处理复杂,且有时背景噪音大,解析有困难,尤其不能对大分子量的化合物或不能对原材料直接进行分析,对肽、多糖等化合物的分析也有一定的困难。但是,最近发展的质谱新技术弥补了这些缺陷。本文主要叙述串联质谱和快原子轰击质谱在天然产物分析中的应用。串联质谱(Tandem Mass Spectrometry),
Mass spectrometry used in natural product analysis is from the 60s of this century. However, early mass spectrometry, such as EIMS, CIMS or FDMS, can only be used for the resolution of small and medium organic molecules. These techniques require high samples, complex pretreatment of the sample, and sometimes background noise is large, analytical difficulties, especially for large molecular weight compounds or raw materials can not be directly analyzed, the analysis of peptides, polysaccharides and other compounds also have some difficult. However, recently developed new mass spectrometry technologies make up for these shortcomings. This article describes the tandem mass spectrometry and fast atom bombardment mass spectrometry in the analysis of natural products. Tandem Mass Spectrometry,