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目的:观察和比较静脉注射地尔硫卓、毛花苷丙控制快速心房颤动心室率的即时疗效及安全性。方法:快速房颤患者58例,采用随机方式分两组,地尔硫卓组35例;毛花苷丙组23例;分别静脉注射地尔硫卓、毛花苷丙。结果:地尔硫卓、毛花苷丙组控制房颤或房扑的快速心室率总有效率分别为93%、69%,心室率平均下降幅度分别为37%、25%,平均起效时间分别为7.4±5.2分钟、31.8±20.8分钟。地尔硫卓组出现可耐受性低血压3例,发生窦性停搏2例,均自行缓解,无心力衰竭加重表现。结论:静脉注射地尔硫卓能迅速、安全、有效控制房颤、房扑的快速心室率。
Objective: To observe and compare the immediate effect and safety of intravenous diltiazem and glycoside C in controlling ventricular rate in patients with atrial fibrillation. Methods: Fifty-eight patients with rapid AF were randomly divided into two groups: 35 patients in diltiazem group and 23 patients in ciliverine group. Intravenous diltiazem and glucosidase C were given respectively. Results: The total effective rate of ventricular tachycardia or atrial flutter control in diltiazem and vinorelbine group was 93% and 69%, respectively. The average decrease rate of ventricular rate was 37% and 25% respectively, and the average effective time was 7.4 ± 5.2 minutes, 31.8 ± 20.8 minutes. In diltiazem group, there were 3 patients with tolerable hypotension and 2 patients had sinus arrest. All patients were relieved spontaneously without worsening of heart failure. Conclusion: Intravenous diltiazem can rapidly, safely and effectively control the rapid ventricular rate of atrial fibrillation and atrial flutter.