论文部分内容阅读
应用苯妥英钠负荷量静脉注射方法,治疗12例惊厥持续状态和反复惊厥的6个月以下小婴儿,临床疗效明显。给予负荷量后30分钟、维持量前、后各30分钟,24(1/2)小时,72(1/2)小时分别取血0.15ml,用EMIT(Syva)法监测血清药物浓度。结果:苯妥英钠负荷量15—20mg/kg静注,30分钟后全部达到有效血药浓度(10—20μg/ml),全部惊厥于静注后5—20分钟停止发作;维持量每次为5—10mg/kg,间隔12—24小时缓慢静注;苯妥英钠静注速度以5—10mg/min为宜。经临床、心电图及血药浓度严密监测,未发现有何毒副作用。
The application of phenytoin load intravenous injection method, the treatment of 12 cases of convulsions and convulsions continued convulsions of infants less than 6 months, the clinical efficacy significantly. At 30 minutes after the administration of the drug, 0.15 ml of blood was collected for 30 minutes, 24 (1/2) hours, and 72 (1/2) hours before maintenance, and the serum drug concentration was monitored by the EMIT (Syva) method. Results: Phenytoin 15-20mg / kg intravenous infusion, 30 minutes after all the effective blood concentration (10-20μg / ml), all convulsions stopped intravenous injection 5-20 minutes; the maintenance dose of 5- 10mg / kg, 12-24 hours interval intravenously; phenytoin sodium injection speed of 5-10mg / min is appropriate. The clinical, ECG and blood concentration monitoring closely, did not find any side effects.