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当前采用的预防Rh疾病的方法是连续和安全地供给抗-D免疫球蛋白以获得被动免疫。根据对RhD蛋白免疫应答的机理及作用于新生儿溶血病(HDN)中的主要靶细胞,可以变更或改进预防策略。这项工作主要集中在确定同种反应辅助T细胞表位上的RhD蛋白。从24个同种免疫RhD阴性患者及8个RhD阴性对照者取外周血单个核细胞(PBMC),用一组68条合
The current approach to preventing Rh disease is to administer anti-D immunoglobulin continuously and safely to obtain passive immunity. Based on the mechanism of immune response to the RhD protein and the primary target cells that act on neonatal hemolytic disease (HDN), prevention strategies can be altered or improved. This work has focused primarily on identifying RhD proteins on alloreactive T-cell epitopes. Peripheral blood mononuclear cells (PBMCs) were obtained from 24 alloimmunized RhD-negative patients and 8 RhD-negative controls using a set of 68