实验性大鼠甲状腺过氧化物酶活性的观察

• 作 者: 刘用章 许广涛
• 机 构: 锦州医学院生化教研组,锦州医学院生化教研组,
• 出 处: 锦州医学院学报
• 发表日期: 1981年Z1期
• 关键词: 大鼠甲状腺 先天性甲状腺肿 甲状腺组织 生成障碍 非毒性 桥本氏甲状腺炎 过氧化物酶 酶蛋白 大鼠 实验鼠

近年来,许多文献报告了甲状腺过氧化物酶(TPO)活性和某些甲状腺疾患有密切的关系。J Stanbury 观察了先天性甲状腺肿(Congenital goiter)的病人是由于其甲状腺组织内碘的有机化发生阻断,并认为这种阻断是由于 TPO 酶蛋白转化为酶这一生化过程发生障碍的结果。因此,认为天先性甲状腺肿是由 TPO 的生成障碍引起。HNiepomniszcze 等报导了非毒性多发结节性甲状腺肿(Nontoxic multinodu-lar goiter),TPO 活性接近或低于正常;桥本氏甲状腺炎(Hashimoto’s thyroidi

In recent years, many papers reported that thyroid peroxidase (TPO) activity and some thyroid disorders are closely related. J Stanbury observed that patients with congenital goiter were blocked by the iodine organisation in their thyroid tissue and that this block was the result of an impediment to the biochemical process by which the TPO enzyme protein was converted to an enzyme . Therefore, it is believed that the predial goiter is caused by the formation of TPO. HNiepomniszcze et al reported nontoxic multinodular goiter, TPO activity near or below normal; Hashimoto’s thyroidi (Hashimoto’s thyroidi