Enantioselective Reduction of Achiral Ketones with NaBH_4/I_2 Catalyzed by (S)-Ferrocenyl Amino Alco

• 出 处: Chinese Chemical Letters
• 发表日期: 2002年10期
• 关键词: alcohols chiral catalyzed Reduction reagent starting asymmetric ketone optically

The reduction reagents prepared from sodium borohydride, I2 and a catalytic amount of chiral ferrocenyl amino alcohols 2a-e have been successfully applied to the enantioselective reduction of ketones. The optically active secondary alcohols were obtained in moderate enantiomeric excess and high chemical yield.

The reduction reagents prepared from sodium borohydride, I2 and a catalytic amount of chiral ferrocenyl amino alcohols 2a-e have been successfully applied to the enantioselective reduction of ketones. The optically active secondary alcohols were obtained in moderate enantiomeric excess and high chemical yield.