A New Method for Synthesis of Methyl 3-Azido-3-deoxy-2-O-mesyl-5-O-benzoylxylofuranoside

• 出 处: Chinese Chemical Letters
• 发表日期: 2002年03期
• 关键词: deoxy pyrimidine moiety Methyl afford dissolved azide substituted hydrolyzed met

A new method for synthesis of 3-azido-3-deoxyxylofuranoside was described. D-ribose was methylated, then treated with methanesulfonyl chloride to give II. II was selectively replaced by benzoate at the 5-position to give III. All these processes gave good yields. III was treated with sodium azide to afford IV, whose structure was determined by 1H NMR and 13C NMR.

A new method for synthesis of 3-azido-3-deoxyxylofuranoside was described. D-ribose was methylated, then treated with methanesulfonyl chloride to give II. II was added by benzoate at the 5-position to give III. All these processes gave good yields. III was treated with sodium azide to afford IV, whose structure was identified by 1H NMR and 13C NMR.