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目的 :探讨川芎嗪对烧伤早期血管内皮细胞的保护作用。方法 :用豚鼠30 %TBSAⅢ度烫伤为模型 ,分为复苏组 (n =48)、治疗组 (n =48)和伤前对照 (n =8)。复苏组在烧伤后立即给予平衡液复苏 ,治疗组在复苏同时给予川芎嗪。分别在伤前、伤后 2、4、8、1 2、2 4和 48小时 ,测定血浆内皮素 (ET)、一氧化氮 (NO) ;在伤后 4和 8小时取回结肠动脉中段作透射电镜观察。结果 :治疗组各时相点ET水平较复苏组低 (P <0 0 5,P <0 0 1 ) ,NO水平无显著性差异 ,两组ET/NO比值比较 ,有显著性差异 (P <0 0 5)。病理显示 ,治疗组血管内皮细胞损害明显轻于复苏组。结论 :川芎嗪对烧伤早期血管内皮细胞有保护作用。
Objective : To explore the protective effect of tetramethylpyrazine on vascular endothelial cells in early burns. METHODS: The guinea pigs were treated with 30% TBSA III degree scald and divided into resuscitation group (n = 48), treatment group (n = 48) and pre-injury control (n = 8). In the resuscitation group, the balanced fluid was resuscitated immediately after the burn, and the treatment group was given ligustrazine at the same time as the resuscitation. Plasma endothelin (ET) and nitric oxide (NO) were measured before injury and 2, 4, 8, 12, 24, and 48 hours after injury, and the middle part of the colonic artery was retrieved at 4 and 8 hours after injury. Transmission electron microscope observation. Results: The ET level in the treatment group was lower than that in the resuscitation group (P<0.05, P<0.01). There was no significant difference in NO level between the treatment group and the ET/NO ratio between the two groups, there was a significant difference (P < 0 0 5). Pathology showed that the damage of vascular endothelial cells in the treatment group was significantly lighter than that in the resuscitation group. Conclusion : Ligustrazine has protective effects on early vascular endothelial cells in burns.