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目的:观察通冠降浊汤联合阿托伐他汀钙片治疗稳定型心绞痛合并高脂血症患者的疗效。方法:将98例患者按随机数字表法分为对照组和中西医结合组各48例。对照组口服阿托伐他汀钙片,中西医结合组在对照组治疗基础上加用通冠降浊汤,疗程为3月。记录每周心绞痛发作次数及硝酸甘油用量,治疗前后进行心电图检查,检测血脂4项。结果:降脂疗效愈显率中西医结合组达85.4%,对照组为64.6%,经比较,差异有统计学意义(P<0.05)。心电图疗效总有效率中西医结合组为89.6%,对照组为70.8%,经比较,差异有统计学意义(P<0.05)。中西医结合组心绞痛发作次数、硝酸甘油用量均少于对照组,差异均有统计学意义(P<0.01)。治疗后,2组总胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白胆固醇(LDL-C)水平均较治疗前下降(P<0.01),高密度脂蛋白胆固醇(HDL-C)水平较治疗前升高(P<0.01);中西医结合组TC水平低于对照组(P<0.01),HDL-C水平高于对照组(P<0.01),2组LDL-C、TG水平比较,差异均无统计学意义(P>0.05)。结论:通冠降浊汤联合阿托伐他汀钙片对稳定型心绞痛合并高脂血症患者的脂代谢有调节作用,并能减少心绞痛发作,降脂疗效和心电图疗效均显著,值得临床使用。
Objective: To observe the effect of Tongguan Jiangzhuo Decoction combined with atorvastatin calcium in patients with stable angina pectoris and hyperlipidemia. Methods: 98 patients were divided into control group and TCM-WM group according to random number table method. Control group oral atorvastatin calcium tablets, the combination of traditional Chinese and Western medicine group in the control group based on the use of Tongguan Jiangzhuo soup, treatment for March. Record the number of angina attacks weekly and the amount of nitroglycerin, ECG before and after treatment, detection of 4 lipids. Results: The effective rate of lipid-lowering effect was 85.4% in the combination of traditional Chinese medicine and western medicine group and 64.6% in the control group, the difference was statistically significant (P <0.05). The total effective rate of ECG was 89.6% in Integrative Medicine Group and 70.8% in Control Group, the difference was statistically significant (P <0.05). The number of angina pectoris and the amount of nitroglycerin in the combination of traditional Chinese and western medicine were less than those in the control group, the difference was statistically significant (P <0.01). After treatment, the levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) in two groups were significantly lower than those before treatment (P <0.01). Compared with the control group, TC levels in the TCM-WM group were lower than those in the control group (P <0.01), HDL-C levels were higher in the TCM-WM group than in the control group There was no significant difference between the two groups (P> 0.05). Conclusion: Tongguan Jiangzhuo Decoction combined with atorvastatin calcium regulates lipid metabolism in patients with stable angina pectoris and hyperlipidemia, and can reduce the incidence of angina pectoris. The effects of lipid lowering and electrocardiogram are significant and worthy of clinical use.