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作者讨论了1968-1986年间加拿大多伦多白血病研究小组遇到的7例在母体宫内接触化疗药物儿童的随访资料,并对近10年英国文献报道的51例妊娠期白血病进行了复习。上述58例妊娠期急性白血病患者,除5例妊娠期间未接受化疗,其余53例均接受不等剂量的化疗剂。在妊娠早中期诊断的病例,其流产及早产率高。本组18个婴儿早产(包括3例死胎)。49例成功娩出活婴。15例产前4周内使用化疗剂,仅5例婴儿出现骨髓抑制。随访情况:文献记载中有7例无任何随访资料,其余病例平均随访时间为1.2年。仅1例出生时有先天异常,未见任何白血病从母体传播给婴儿的病例,亦无关于宫内接触化疗剂儿童继发白
The authors discussed the follow-up of seven children with intrauterine exposure to chemotherapeutic drugs encountered by the Toronto Leukemia Research Group from 1968 to 1986 in Canada and reviewed 51 cases of gestational leukemia reported in the UK in the last 10 years. The 58 cases of acute leukemia in pregnancy, except for 5 cases of pregnancy did not receive chemotherapy, the remaining 53 patients received varying doses of chemotherapy. Early diagnosis of pregnancy in the case of abortion and premature delivery rate. The group of 18 infants premature (including 3 stillbirths). 49 cases of successful delivery of live babies. Fifteen of the 15 patients received chemotherapy during the first 4 weeks of prenatal treatment and only 5 of the infants developed myelosuppression. Follow-up: There are 7 cases in the literature without any follow-up information, the average follow-up time of the remaining cases was 1.2 years. Only 1 case of congenital anomalies at birth, no cases of leukemia transmitted from mother to infant, nor about intrauterine exposure to chemotherapy in children with secondary white