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目的研究安徽省流脑流行特征和流脑菌群变异状况,为控制流脑流行提供依据。方法在2003~2004年度流脑疫情处理过程中,采集病人脑脊液2份,密切接触者咽拭子700份,用卵黄双抗琼脂培养基直接分离置37℃5%~10%二氧化碳条件下培养18~24h,取可疑菌落进行血清学鉴定及生化、药敏试验。结果从病人脑脊液和密切接触者咽拭子中分离培养出C群脑膜炎奈瑟氏双球菌74株,A群脑膜双球菌11株,B群脑膜双球菌19株。结论安徽省2003~2004年的流脑疫情是以C群流脑为主的流行。先锋V等青霉素类药对C群流脑菌株敏感。
Objective To study the epidemiological characteristics of meningococcal meningitis and the variation of meningococcal flora in Anhui Province and provide basis for controlling the prevalence of meningococcal meningitis. Methods During the treatment of meningococcal disease in 2003-2004, 2 cerebrospinal fluid (CSF) and 700 throat swabs from close contacts were collected and directly cultured with yolk double-agar medium at 37 ° C and 5% -10% CO2 for 18 ~ 24h, take suspicious colonies for serological identification and biochemical, susceptibility testing. Results 74 strains of Neisseria meningitidis group C, 11 strains of meningococcal group A and 19 strains of meningococcal group B were isolated and cultured from cerebrospinal fluid and throat swabs of close contacts. Conclusions The epidemic of meningitis in Anhui Province from 2003 to 2004 was mainly epidemic in Group C meningitis. Pioneer V and other penicillins are sensitive to Group C meningitis.