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目的探讨体检人群超敏C反应蛋白(hs-CRP)水平与血浆致动脉硬化指数(AIP)、非高密度脂蛋白胆固醇(non-HDL-C)水平相关性及临床意义。方法随机选择从2004年1月～2009年12月在温州医学院附属第一医院体检中心参与体检的12 062例人员,测定甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、hs-CRP,计算出non-HDL-C、AIP;并按hs-CRP水平及性别进行分组。数据采用SPSS13.0统计软件,组间比较用t检验,P<0.05为差异有统计学意义。结果该研究人群hs-CRP异常率为58.2%(7 020/12 062),男性hs-CRP异常率66.4%(4 040/6 081)明显高于女性49.8%(2 981/5 981)(χ2=1 063.16,P=0.000),hs-CRP水平也存在明显性别差异;在男性人群中,随hs-CRP水平升高,研究指标中仅AIP水平出现增高(F=4.111,P=0.017),相关分析显示hs-CRP仅与AIP呈正相关(r=0.114,P=0.047);在女性人群中,随hs-CRP水平升高,TG、HDL-C、non-HDL-C、AIP、低密度脂蛋白胆固醇(LDL-C)水平出现增高(F=14.351、4.722、6.119、16.825、3.233,P=0.000、0.010、0.002、0.000、0.041),相关分析显示hs-CRP与TG、AIP呈正相关(r=0.162、0.200,P=0.005、0.000),与HDL-C呈负相关(r=-0.121,P=0.036)。结论 hs-CRP水平有明显性别差异,男性hs-CRP异常率明显高于女性;hs-CRP与AIP有正相关,而与non-HDL-C无明显相关性;联合检测AIP、hs-CRP比其他血脂指标可能更好地预测价值,反映健康人群首发心血管事件。
Objective To investigate the correlation between the levels of hs-CRP and the levels of atherogenic index (AIP) and non-HDL-C in the physical examination population and its clinical significance. Methods A total of 12 062 participants who participated in the physical examination from the First Affiliated Hospital of Wenzhou Medical College from January 2004 to December 2009 were selected for determination of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), hs-CRP, calculated non-HDL-C, AIP; and hs-CRP levels and gender groups. Data using SPSS13.0 statistical software, t test between groups, P <0.05 for the difference was statistically significant. Results The abnormal rate of hs-CRP in this study population was 58.2% (7 020/12 062). The abnormal rate of hs-CRP in male was 66.4% (4040/6 081), which was significantly higher than that of female 49.8% (2 981/5 981) (χ2 = 1 063.16, P = 0.000). There was also a significant gender difference in hs-CRP levels. Only the levels of AIP were increased (F = 4.111, P = 0.017) in the male population as the level of hs- Correlation analysis showed that there was a positive correlation between hs-CRP and AIP (r = 0.114, P = 0.047). In the female population, the levels of TG, HDL-C, The level of serum lipoprotein cholesterol (LDL-C) increased (F = 14.351,4.722,6.119,16.825,3.233, P = 0.000,0.010,0.002,0.000,0.041). Correlation analysis showed that hs-CRP was positively correlated with TG and AIP r = 0.162,0.200, P = 0.005,0.000), and negatively correlated with HDL-C (r = -0.121, P = 0.036). Conclusion The hs-CRP level has significant gender difference. The abnormal rate of hs-CRP in males is obviously higher than that in females. There is a positive correlation between hs-CRP and AIP but not with non-HDL-C. Other lipid markers may predict the value better, reflecting the first cardiovascular events in healthy people.