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本文报告采用Lovastatin、普罗布可(Probucol)、考来替泊(Colestipol)等3种药物的不同联合用药方案治疗家族性血胆固醇过多的效果。 17例患者,既往至少对2种以上抗胆固醇过多药物无效。用药方法:每例患者以不同方法联用考来替泊(10mg,每天2次)、普罗布可(500mg,每天2次)、Lovastatin(20 mg或40mg,每天2次),用药25个月。结果表明,Lovastatin(每日40mg)始终降低低密度脂蛋白(LDL)水平36%,普罗布可仅降低LDL14%。Lovastatin联合普罗布可降低的LDL值,并不优于单独使用Lovastatin者。Lovastatin联用考来替泊使LDL降低52%。再加用普罗布可,并不能使LDL更降低。Lovastatin(每日80mg)加用考来替泊,使LDL降低56%。Lovastatin增加高密度脂蛋白胆固醇达6%,而普
This article reports the effects of different combination regimens of familial hypercholesterolemia with three drugs, Lovastatin, Probucol, Colestipol. Seventeen patients were previously ineffective with at least two anti-hypercholesterolemic agents. Medication: Each patient was given coutrol (10 mg twice daily), probucol (500 mg twice daily), Lovastatin (20 mg or 40 mg twice daily) in different combinations for 25 months . The results showed that Lovastatin (40 mg daily) consistently reduced LDL levels by 36% and probucol reduced LDL by only 14%. Lovastatin combined with probucol reduced LDL values, not better than those who use lovastatin alone. Lovastatin plus colestipox reduced LDL by 52%. Add probucol, can not make LDL lower. Lovastatin (80 mg daily) plus colestipol reduced LDL by 56%. Lovastatin increases HDL cholesterol by 6%, while Pu