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本文对阿霉素磁性白蛋白微球在大鼠体内分布的情况进行研究,结果表明,在外加磁场的条件下,药物能浓集在特定的靶组织中,并相应地降低药物在其它组织中的分布。磁性微球剂的制备:取牛血清白蛋白水溶液(400mg/ml)250μl,磁铁矿100mg 和盐酸阿霉素水溶液(50mg/ml)200μl 混合后,加入30ml 棉籽油,于4℃用超声波(125W)匀化2min,然后将磁性乳液以100滴/min 的速度加至100ml 预热的棉籽油(120±5℃)中,搅拌(1500r/min)10min 后冰浴冷至20℃,用60ml 无水乙醚洗4次,每次离心(3000×g)15min,将制成的微球乙醚混悬液移置带有条
In this paper, doxorubicin magnetic albumin microspheres distribution in rats were studied, the results show that under the conditions of applied magnetic field, the drug can be concentrated in a specific target tissue and correspondingly reduce the drug in other tissues Distribution. Preparation of Magnetic Microspheres: 250 μl of a bovine serum albumin aqueous solution (400 mg / ml), 100 mg of magnetite and 200 μl of an aqueous doxorubicin hydrochloride solution (50 mg / ml) were mixed and then 30 ml of cottonseed oil was added thereto, 125W) homogenized for 2min, and then the magnetic emulsion 100mL / min speed added to 100ml preheated cottonseed oil (120 ± 5 ℃), stirred (1500r / min) 10min after the ice bath cooled to 20 ℃ with 60ml Anhydrous ether 4 times, each centrifugation (3000 × g) 15min, the resulting suspension of microspheres ether suspension with a strip