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目的:分析双水平气道正压(BiPAP)联合无创机械通气(NIV)对慢性阻塞性肺部疾病(COPD)合并呼吸衰竭的治疗效果。方法:将52例COPD合并呼吸衰竭患者随机分为两组各26例,对照组以常规方法治疗,观察组在常规治疗基础上行BiPAP与NIV联合治疗,比较两组治疗效果。结果:治疗后观察组呼吸频率、心率、PaO_2、PaCO_2及APACHEⅡ评分均明显优于对照组(P<0.05),患者住院时间明显短于对照组(P<0.05)。两组治疗期间不良反应发生率无显著差异(P>0.05),且均未发生严重不良反应。结论:BiPAP与NIV联合疗法可促使COPD合并呼吸衰竭患者的体征及动脉血气情况得到明显改善,有助于缩短住院时间,且不会引发严重不良反应,值得推广。
Objective: To analyze the therapeutic effect of bi-level positive airway pressure (BiPAP) combined with noninvasive mechanical ventilation (NIV) on chronic obstructive pulmonary disease (COPD) with respiratory failure. Methods: Fifty-two COPD patients with respiratory failure were randomly divided into two groups of 26 patients. The control group was treated by conventional method. The observation group was treated with BiPAP combined with NIV on the basis of routine treatment. The therapeutic effect was compared between the two groups. Results: After treatment, the respiratory rate, heart rate, PaO_2, PaCO_2 and APACHEⅡ scores in the observation group were significantly better than those in the control group (P <0.05). The hospitalization time was significantly shorter in the observation group than in the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05), and no serious adverse reactions occurred. Conclusion: The combination therapy of BiPAP and NIV can significantly improve the signs and arterial blood gas of COPD patients with respiratory failure, shorten the length of hospital stay, and not cause serious adverse reactions, which is worth promoting.