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应用正常的和无胸腺的(裸体的)BALB/C 和 C3H/He J 鼠研究了流产布氏菌1119—3菌苗(BA)以及有生物学活性的流产布氏菌脂多糖(BA—LPS)的免疫学和促有丝分裂特性。虽然流产布氏菌能使所有的小鼠都产生对二巯基乙醇敏感的首次和二次抗体反应,但是与正常的 BALB/C 和 C3H/He J 小鼠比较,裸体小鼠不产生典型的抗二巯基乙醇的抗体反应。同样,所有注射流产布氏菌脂多糖的小鼠都产生二巯基乙醇敏感的首次反应。有胸腺小鼠的二次反应中包含一种真正的抗二巯基乙醇抗体成分。总起来说,这些观察说明虽然流产布氏菌及其脂多糖都能刺激无胸腺参与的对二巯基乙醇敏感的挠体的合成,但是,最令人满意的含有抗二巯基乙醇成分的免疫反应需要胸腺诱导细胞参与。正常的 BALB/C 和 C3H/He J 小鼠对流产布氏菌及其脂多糖的抗体反应,在质和量上是相同的。流产布氏菌及其脂多糖能引起正常的和裸体的 BACB/C 和 C3H/He J 两种小鼠的脾细胞的有丝分裂反应。但是,不能引起正常的 BALB/C 和 C3H/He J 小鼠的胸腺细胞的有丝分裂。这说明两种制剂都是促 B 细胞有丝分裂制剂。
Both B. abortus 1119-3 vaccine (BA) and the biologically active aborted B. luteus lipopolysaccharide (BA-LPS) were studied using both normal and athymic (nude) BALB / c and C3H / ) Immunological and mitogenic properties. Although B. abortus was able to produce both primary and secondary antibody responses to all dimercaptoethanol in all mice, nude mice did not develop typical anti-tumor responses compared to normal BALB / C and C3H / He J mice Antibody reaction of dimercaptoethanol. Similarly, all mice injected with L. abortus lipopolysaccharide produced the first dimercaptoethanol-sensitive response. Secondary reactions in thymus mice include a true anti-dimercaptoethanol antibody component. Taken as a whole, these observations indicate that although both B. luteus and its lipopolysaccharides stimulate the synthesis of dimercaptoethanol-sensitive fusorium in the absence of thymus, the most satisfactory immune response to dithiol-containing ethanol components Thymus-induced cell involvement is required. Antibody responses to B. luturasis and its lipopolysaccharides in normal BALB / c and C3H / He J mice are qualitatively and qualitatively identical. B. abortus and its lipopolysaccharide cause mitogenic responses in splenocytes of both normal and nude BACB / C and C3H / He J mice. However, it did not elicit mitosis in thymocytes of normal BALB / c and C3H / He J mice. This shows that both formulations are B-cell mitogenic agents.