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二十五年来,用杂环类抗抑郁剂或MA-OI治疗情感性障碍和焦虑性障碍的疗效已得到肯定。然而,由于病人不能耐受或由于医生的缘故,用药剂量常常不足。Keller等报告:连续入院符合RDC诊断标准的200多名重症抑郁患者,只有34%治疗超过了四周,只有12%达到了合适的剂量(丙咪嗪300mg/日或相当的剂量)。作者认为:造成这种情况,是因为一些医生过份担心这类药物的副
Twenty-five years, with heterocyclic antidepressants or MA-OI treatment of affective disorders and anxiety disorders have been affirmed. However, due to the patient’s intolerance or due to the doctor, the dosage is often inadequate. Keller et al. Reported that only over 34% of the more than 200 patients with severe depression who met the RDC diagnostic criteria were admitted for more than four weeks and only 12% achieved the appropriate dose (imipramine 300 mg / day or equivalent). The author thinks: This situation is caused because some doctors worry too much about the side effects of such drugs