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本文报道了9个香豆素衍生物对小鼠的抗辐射作用。其中4-甲基-6-烯丙基-7-乙酰氧基香豆素(8211),4,5′-二甲基呋喃并香豆素(8214),4-甲基-7-羟基-8-烯丙基香豆素(8216),4-甲基-7-乙酰氧基-8-烯丙基香豆素(8224)和补骨脂素(即呋喃并香豆素,8406)于照前给药有抗放作用,而8211,8216和8224照后给药亦有效。8224照前给药对骨髓型辐射损伤的剂量减低系数(DRF)为1.24,对肠型损伤小鼠能提高照后7天活存率26％;照后给药对骨髓型损伤小鼠可提高活存率60％。这类化合物对造血组织的辐射损伤亦有显著的保护作用。
This article reports the anti-radiation effects of nine coumarin derivatives on mice. Among them, 4-methyl-6-allyl-7-acetoxycoumarin (8211), 4,5’-dimethylfuranocoumarin (8214) Allylic coumarin (8216), 4-methyl-7-acetoxy-8-allylcoumarin (8224) and psoralen (ie furocoumarin, 8406) Antibiotics were administered prior to irradiation, but administration after 8211, 8216 and 8224 was also effective. The dose-reduction coefficient (DRF) of 8224 irradiation on bone marrow-typed radiation injury was 1.24, and the survival rate of intestinal-typed mice was increased by 26% after 7 days of irradiation. After irradiation, the bone marrow-injured mice could be improved Live survival rate of 60%. These compounds also have a significant protective effect on the radiation damage of hematopoietic tissues.