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Objective: To investigate factors that contribute to lymph node metastasis(LNM) from clinical cT2-T4 N0M0(cN0) supraglottic laryngeal carcinoma(SLC), and to predict the risk of occult metastasis before surgery.Methods: A total of 121 patients who received surgery were retrospectively analyzed. Relevant factors regarding cervical LNM were analyzed. Multivariate analyses were conducted to predict the region where the metastasis occurred and prognosis. Results: The overall metastatic rate of c N0 SLC was 28.1%. Metastatic rates were 15.4%, 32.5% and 35.7% for T2, T3 and T4, respectively. Metastatic rates for SLC levels II, III and IV were 19.6%, 17.2% and 3.6%, respectively. A regression equation was formulated to predict the probability of metastasis in cN0 SLC as follows: Pn=e(–3.874+0.749T3+1.154T4+1.935P1+1.750P2)/[1+e(–3.874+0.749T3+1.154T4+1.935P1+1.750P2)]. Approximately 0.2% of patients experienced LNM with no recurrence of laryngeal cancer. Comparison of the intergroup survival curves between patients with and without LNM indicated a statistically significant difference(P=0.029).Conclusions: Cervical lymph node metastatic rates tended to increase in tandem with T stage in patients with LNM in cN0 SLC, and neck dissection is advised for these patients. Moreover, cervical LNM in cN0 SLC showed a sequential pattern and may be predicted.
Objective: To investigate factors that contribute to lymph node metastasis (LNM) from clinical cT2-T4 N0M0 (cN0) supraglottic laryngeal carcinoma (SLC), and to predict the risk of occult metastasis before surgery. Methods: A total of 121 patients who received Multivariate analyzes were performed to predict the region where the metastasis occurred and prognosis. Results: The overall metastatic rate of c N0 SLC was 28.1%. Metastatic rates were 15.4%, 32.5% respectively. A regression equation was formulated to predict the probability of metastasis in cN0 SLC as follows (Table 1), and 35.7% for T2, T3 and T4, respectively. Metastatic rates for SLC levels II, III and IV were 19.6%, 17.2% and 3.6%, respectively. : Pn = e (-3.874 + 0.749T3 + 1.154T4 + 1.935P1 + 1.750P2) / [1 + e (-3.874 + 0.749T3 + 1.154T4 + 1.935P1 + 1.750P2)] Approximately 0.2% of patients experienced LNM with no recurrence of laryngeal cancer. Comparison of the intergroup surviv al curves between patients with and without LNM showed a statistically significant difference (P = 0.029) .Conclusions: Cervical lymph node metastatic rates tended to increase in tandem with T stage in patients with LNM in cN0 SLC, and neck dissection was advised for these patients Moreover, cervical LNM in cN0 SLC showed a sequential pattern and may be predicted.