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目的 :分析和比较普通阿司匹林、阿司匹林肠溶片临床应用胃肠道的不良反应情况。方法 :选取某院在2014年12月~2015年12月期间收治的148例患者,按照随机分配原则将所有患者分为参照组和研究组,各74例患者。其中参照组采用普通阿司匹林治疗,研究组患者采用阿司匹林肠溶片治疗,观察和比较两组患者的胃肠道不良反应发生情况。结果 :参照组患者中共有12例患者出现胃肠道不良反应,其不良反应发生率为16.22%;研究组患者中共有3例患者出现胃肠道不良反应,其不良反应发生率为4.05%。研究组患者的胃肠道不良反应发生率要明显低于参照组患者胃肠道不良反应的发生率,p<0.05,差异比较具有统计学意义。结论 :采用普通阿司匹林治疗比阿司匹林肠溶片治疗的临床应用胃肠道不良反应发生率高,这也就表示在临床治疗的过程中,阿司匹林肠溶片的安全性比较高,在临床治疗中值得推广。而且对于患者胃溃疡的患者来说,阿司匹林肠溶片的应用价值和好处还需要进一步的进行研究和证明。
OBJECTIVE: To analyze and compare the gastrointestinal adverse reactions of aspirin and aspirin in clinical application. Methods: A total of 148 patients were selected from a hospital from December 2014 to December 2015. According to the principle of random assignment, all patients were divided into the reference group and the study group, each of 74 patients. The reference group was treated with aspirin. The patients in the study group were treated with aspirin enteric-coated tablets. The incidence of gastrointestinal adverse reactions was observed and compared between the two groups. Results: A total of 12 patients in the reference group had gastrointestinal adverse reactions with a rate of 16.22%. A total of 3 patients in the study group had gastrointestinal adverse reactions with a rate of 4.05%. The incidence of gastrointestinal adverse reactions in the study group was significantly lower than that of the reference group, p <0.05, the difference was statistically significant. Conclusions: The clinical application of aspirin in the treatment of aspirin enteric-coated tablets has a high incidence of gastrointestinal adverse reactions, which means that the safety of aspirin enteric-coated tablets is high during clinical treatment and worthwhile in clinical treatment Promotion. And for patients with gastric ulcer patients, the value and benefits of aspirin enteric-coated tablets need further study and certification.