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目的:认真探讨总结他克莫司的药理作用,并研究掌握该药物的临床治疗效果,为后续的临床应用提供参考。方法:以翻阅文献法认真归纳并总结他克莫司药物的重要药理作用、临床疗效、不良反应以及不同药物共存后的药效变化等。结果:他克莫司的药理作用主要体现为:强效免疫抑制、促神经再生;对异位性湿疹、类风湿性关节炎、重症肌无力等疾病的治疗效果显著;可在多种药物共用时产生不良药效反应,诱发神经毒性、心肌增厚、牙龈增生等病症。结论:他克莫司是具有代表性的临床应用药物,不断加强其药理作用的研究,总结其临床疗效,掌握其不同药物的药效变化与不良反应,有助于在临床中广泛推广。
Objective: To seriously study and summarize the pharmacological effects of tacrolimus, and to study and master the clinical efficacy of the drug for the follow-up clinical application. Methods: To review the literature method to summarize and summarize the important pharmacological effects of tacrolimus, clinical efficacy, adverse reactions and changes in the efficacy of different drugs coexist. Results: The pharmacological effects of tacrolimus were mainly manifested as: potent immunosuppression and neurotrophic regeneration; the therapeutic effect on atopic eczema, rheumatoid arthritis, myasthenia gravis and other diseases was significant; When adverse drug reactions, induced neurotoxicity, myocardial thickening, gingival hyperplasia and other diseases. Conclusion: Tacrolimus is a representative clinical application of drugs, and continue to strengthen its pharmacological effects, summarize its clinical efficacy, to master the efficacy of different drugs and adverse reactions, will help promote the widespread in the clinic.