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胸腺素β4是一种多功能多肽,广泛分布于有核细胞中,目前涉及组织修复和再生方向已成功应用于临床试验。随着研究的深入,关于胸腺素β4对细胞分化成熟、创伤修复和血管再生方面的研究进展,目前有了最新的认识。近年来对胸腺素β4的研究包括在血管生成、创伤愈合和毛囊再生等方面,根据其多种生物学活性,在组织修复和再生方面已进行多项动物实验研究。因此,胸腺素β4对于整形外科具有潜在的临床应用价值。这篇综述首先更新了胸腺素β4再生活性中基础的细胞集联和途径信息;其次,描述了胸腺素β4潜在的临床应用。
Thymosin β4 is a multi-functional peptide, widely distributed in nucleated cells, the current tissue repair and regeneration directions have been successfully applied to clinical trials. With the deepening of the research, there is a new understanding on the research progress of thymosin β4 on cell differentiation and maturation, wound repair and angiogenesis. Recent studies on thymosin β4 have included a number of animal studies in tissue repair and regeneration in terms of angiogenesis, wound healing, and hair follicle regeneration, based on their diverse biological activities. Therefore, thymosin β4 for plastic surgery has potential clinical value. This review first updated the information on cell assembly and pathway underlying thymosin β4 reactivation activity. Second, the potential clinical application of thymosin β4 was described.