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1977年有人在行阴茎血管手术时偶然发现在阴茎海绵体内注入罂粟碱,阴茎勃起可持续2小时之久。1983年Brindly报告,海绵体内注入酚苄明勃起可达30小时。其后Virag及Zorgnitti几乎同时单用罂粟碱或合用酚妥拉明于阴茎根部注射治疗阳萎。近几年来,阳萎治疗的重要进展就是血管活性药物罂粟碱及α-肾上腺素能阻滞剂的使用。目前国内也有人用以上两种药物治疗阳萎。这样就增加了药物所致阴茎持续勃起(pharmacologically induced prolonged erection,PIPE)的发生机会。一、血管活性药物的作用机理阴茎勃起是由神经冲动引起的,神经冲动是由盆神经(含副交感神经纤维)及腰交感
In 1977 some people in the penile vascular surgery occasionally found in the penis cavernous injection of papaverine, penile erection can last 2 hours. In 1983 Brindly reported sponge injection of phenoxybenzamine up to 30 hours. Virag and Zorgnitti were treated with papaverine or phentolamine alone almost simultaneously in the penile roots for impotence. In recent years, significant advances in impotence treatment have been the use of the vasopressin and alpha-adrenergic blockers. At present, some people use the above two kinds of drugs to treat impotence. This increases the chances of pharmacologically induced prolonged erection (PIPE). First, the mechanism of action of vasoactive drugs Penile erection is caused by nerve impulses, nerve impulses by the pelvic nerve (including parasympathetic fibers) and lumbar sympathetic