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在慢性肾衰病人,含铝化合物一直是结合饮食中磷以控制继发甲旁亢的主要药物。然而,在肾衰时肾脏不能排出过量的铝而发生组织积蓄。脑、骨中铝过多将产生脑病,骨软化等。因此,对不含铝的磷结合剂产生了兴趣。业已证明,碳酸钙能有效地控制高磷血症和低钙血症。枸椽酸钙能够结合饮食中的磷及补充钙。理论上,枸椽酸钙应该能控制高磷血症和低钙血症。此外,通过提供碱基而有效
In patients with chronic renal failure, aluminum-containing compounds have been the primary drug that combines phosphorus in the diet to control secondary hyperparathyroidism. However, in the case of renal failure, the kidneys can not excrete excess aluminum and tissue accumulation occurs. Brain, too much aluminum in bones will produce encephalopathy, osteomalacia and so on. Therefore, there is interest in aluminum-free phosphorus binders. It has been demonstrated that calcium carbonate effectively controls hyperphosphatemia and hypocalcemia. Calcium citrate combines dietary phosphorus and calcium supplements. In theory, calcium citrate should be able to control hyperphosphatemia and hypocalcemia. In addition, it is effective by providing a base