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目的:通过比较急性心肌梗死(AMI)患者发病后不同时点血浆N端脑钠肽前体(NT-proBNP)水平与发病6个月后左室舒张末期内径(LVDd)、左心室射血分数(LVEF)的相关性,探讨不同时点血浆NT-proBNP水平对AMI发病后左心室重构预测价值的差别。方法:NT-proBNP检测试剂盒检测116例AMI患者发病后12、24、36 h血浆NT-proBNP水平,并随访患者发病6个月后LVDd、LVEF。结果:发病后12、24、36 h血浆NT proBNP水平与6个后月后LVDd的相关系数分别为0.52、0.78、0.64,与LVEF的相关系数分别为-0.47、-0.81、-0.51(均P<0.05)。其中24 h的相关系数与12及36 h的比较差异有统计学意义(P<0.05)。结论:与发病后12、36 h相比较,发病后24 h的血浆NT-proBNP水平可以更好预测AMI发病6个月后的左心室重构。
Objective: To compare the levels of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) and left ventricular end diastolic diameter (LVDd), left ventricular ejection fraction (LVEF) in patients with acute myocardial infarction (AMI) to explore the difference of the predictive value of plasma NT-proBNP at different time points after AMI. Methods: NT-proBNP kit was used to detect plasma NT-proBNP levels in 116 AMI patients at 12,24,36 h after onset and follow-up of patients with LVDd and LVEF after 6 months. Results: The correlation coefficients of NT proBNP level at 6 months, 12 months, 24 hours, and 6 months after LVDD were 0.52, 0.78, 0.64, respectively, and the correlation coefficients with LVEF were -0.47, -0.81, -0.51 <0.05). The correlation coefficient of 24 h was significantly different from that of 12 and 36 h (P <0.05). CONCLUSIONS: Plasma NT-proBNP levels at 24 h postinfarction may be a better predictor of left ventricular remodeling after 6 months of onset of AMI compared to 12 and 36 h after onset.