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观察了肾血管性高血压大鼠(RHT)和正常血压大鼠(Wistar)动脉血中6-Keto-PGF_(1a)和 TXB_2浓度及其比值变化,以及肾髓质中 PGE_2含量和动脉血中 AT-Ⅱ浓度。同时检测了狭窄双肾动脉后肾组织之形态改变。结果表明,RHT 大鼠动脉血中6-Keto-PGF_(1a)浓度和6 Keto/TXB_2比值均低于Wistar 鼠;血中 AT-Ⅱ浓度则明显高于 Wistar 鼠。RHT 大鼠在狭窄双肾动脉后第七周末与 Wistar 鼠进行形态学比较,无特异性改变。研究结果提示,动脉血中 AT-Ⅱ浓度升高与肾血管性高血压的发生密切相关,而血中 6-Keto-PGF_(1a)浓度降低以及6-Keto/TXB_2比值减少,可能有助于高血压的持续发展。
The changes of 6-Keto-PGF_ (1a) and TXB_2 in arterial blood and the ratio of PGE_2 in the renal medulla and arterial blood were observed in renal vascular hypertensive rats (RHT) and normal blood pressure rats (Wistar) AT-Ⅱ concentration. At the same time, the morphological changes of renal tissue after stenosis were detected. The results showed that the concentration of 6-Keto-PGF_ (1a) and the ratio of 6 Keto / TXB_2 in arterial blood of RHT rats were lower than that of Wistar rats. The AT-Ⅱ concentration in blood was significantly higher than that of Wistar rats. RHT rats were morphologically compared with Wistar rats at the end of the seventh weekend after stenosis of the bilateral renal arteries, with no specific changes. The results suggest that elevated arterial blood AT-Ⅱ concentration and renal vascular hypertension are closely related to the blood 6-Keto-PGF_ (1a) concentration and 6-Keto / TXB_2 ratio may be helpful The continuous development of hypertension.