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通过简单的溶剂扩散法,在合成E环开环衍生物的配合物的过程中,得到了一个新型喜树碱非内酯环类似物2,并通过元素分析、IR、X-射线单晶衍射对其进行了结构表征。结果表明,化合物2(C19H18N2O4)属于单斜晶系Cc,a=2.2432(5),b=9.7320(19),c=7.4280(15),β=97.95(3)°,Z=2,V=1606.0(6)3,Mr=338.35,F(000)=712,R=0.0456,wR=0.1090。结构分析表明,化合物2的每个分子由1个喜树碱类似物分子和1个水分子组成,2个喜树碱类似物分子通过短程相互作用形成柱状堆积,相邻的柱状堆积通过与水分子之间的氢键作用形成二维网络结构。
A novel camptothecin non-lactone ring analogue 2 was obtained by the simple solvent diffusion method during the synthesis of the ring-opening derivative of E-ring. The results of elemental analysis, IR and X-ray single crystal diffraction Its structure was characterized. The results show that compound 2 (C19H18N2O4) belongs to monoclinic Cc, a = 2.2432 (5) , b = 9.7320 (19) , c = 7.4280 , V = 1606.0 (6) 3, Mr = 338.35, F (000) = 712, R = 0.0456, wR = 0.1090. Structural analysis showed that each molecule of Compound 2 consisted of one camptothecin analog molecule and one water molecule, and two camptothecin analog molecules formed a columnar packing by short-range interactions, Hydrogen bonding between molecules forms a two-dimensional network structure.